![]() ![]() ![]() ![]() Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. These findings suggest that dietary patterns high in fruits, vegetables, and low-fat foods and low in processed foods may be useful in avoiding exposure to phthalates. DISCUSSION: Higher dietary alignment with DASH and aMed dietary patterns were significantly associated with lower concentrations of certain phthalate biomarkers, while an inflammatory diet pattern was associated with higher phthalate biomarker concentrations. DII scores were positively associated with mono benzyl phthalate and the sum of di-n-butyl phthalate. DASH and aMed scores were also inversely associated with mono benzyl phthalate and mono-3-carboxypropyl phthalate. We fit multivariable generalized estimating equation models to estimate the cross-sectional associations. We measured 13 phthalate metabolites and creatinine in 2-3 urine samples per participant collected over 3-years when all participants were cancer-free. We used these data to calculate scores for alignment with the Dietary Approach to Stop Hypertension (DASH), alternative Mediterranean (aMed), and Dietary Inflammatory Index (DII) diets. Dietary intake was measured via self-administered food frequency questionnaires at baseline and year-3. METHODS: We included WHI participants selected for a nested case-control study of phthalates and breast cancer (N = 1240). OBJECTIVES: We evaluated the associations between dietary patterns and urinary phthalate biomarkers among a subset of postmenopausal women participating in the Womens Health Initiative (WHI). Diet is a primary source of exposure, but prior studies exploring associations between dietary patterns and phthalate exposure are limited. BACKGROUND: Phthalates are endocrine-disrupting chemicals linked to a higher risk of numerous chronic health outcomes. ![]()
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